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Weight loss medications like GLP-1 agonists are proving effective, but experts emphasize that sustainable results require a significant shift in lifestyle habits. Dr. Ana Maria Kausel, an endocrinologist, explains that the body naturally attempts to return to its previous weight after initiating medication, underscoring the importance of long-term behavioral changes.

According to Dr. Kausel, the body’s inherent resistance to weight loss is a crucial factor. When a patient begins taking a GLP-1 medication, the body recognizes this change and actively works to regain the weight previously lost. This physiological response highlights that medication alone is insufficient for achieving lasting weight management.

GLP-1 agonists, such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro), work by mimicking a natural hormone that regulates appetite and blood sugar. They slow down the emptying of the stomach and increase feelings of fullness, leading to reduced food intake and, consequently, weight loss. While these medications can be powerful tools, their effectiveness is significantly amplified when combined with a comprehensive approach to health.

Dr. Kausel’s advice centers on adopting a sustainable lifestyle that incorporates healthy eating habits and regular physical activity. This includes mindful consumption, portion control, and making informed food choices. Regular exercise helps build muscle mass, which boosts metabolism and further supports weight management. The focus should be on creating long-term habits that can be maintained even after discontinuing the medication, if that becomes necessary or desired.

Ultimately, GLP-1 medications provide a valuable aid in the weight loss journey, but they are most effective when used as part of a broader strategy that prioritizes lifestyle modifications and addresses the underlying factors contributing to weight gain. Ignoring the need for these changes risks a return to previous weight, negating the benefits of the medication.